When you are making big altitude change your speed will be lower. Maybe it wil drop even to 1 kilometer per hour. You should also incalculate time for breaks in your tour. The basics as I understand it (please correct me if I am wrong) is that the Frailty Curse kills a mob when the mobs health hits 15%. The method that Bliz used was to hit that mob with a huge damage tick. The Marked for Death Grim Reaper skill applies 15% of damage dealt to all mobs within 20 yards.

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